Anti-eIF2D monoclonal antibody (DCABH-11382) Made to order

Rabbit anti-Human eIF2D monoclonal antibody for WB, ELISA

View other eIF2D antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human EIF2D is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
EIF2D; eukaryotic translation initiation factor 2D; LGTN; ligatin; hepatocellular carcinoma-associated antigen 56; HCA56
Entrez Gene ID
UniProt ID

Product Background


Gene summary
EIF2D (Eukaryotic Translation Initiation Factor 2D) is a Protein Coding gene. GO annotations related to this gene include RNA binding and translation initiation factor activity. This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively. Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Ligatin is a protein that in humans is encoded by the LGTN gene. 0The function about eIF2D antigen include RNA binding; receptor activity; translation initiation factor activity.

Citations


Have you cited DCABH-11382 in a publication? Let us know and earn a reward for your research.

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

References


Cerrudo, CS; Ghiringhelli, PD; et al. Protein universe containing a PUA RNA-binding domain. FEBS JOURNAL 281:74-87(2014).
Dmitriev, SE; Terenin, IM; et al. GTP-independent tRNA Delivery to the Ribosomal P-site by a Novel Eukaryotic Translation Factor. JOURNAL OF BIOLOGICAL CHEMISTRY 285:26779-26787(2010).

Online Inquiry

Name:
Phone: *
E-mail Address: *
Service & Products Interested: *
Project Description:
Verification Code: * Please input "diagnostics" as verification code.

Online Inquiry

  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket