Anti-EHMT2 monoclonal antibody (DCABH-2735) Knockout Validated

Rabbit anti-Human EHMT2 monoclonal antibody for WB, IHC-P

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS5120(3)
Species Reactivity
Human
Immunogen
Synthetic peptide from near the C-terminus of Human KMT1C/ G9a (UniProt ID: Q96KQ7)
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
EHMT2; euchromatic histone-lysine N-methyltransferase 2; BAT8, C6orf30, chromosome 6 open reading frame 30 , HLA B associated transcript 8; histone-lysine N-methyltransferase EHMT2; Em:AF134726.3; G9A
Entrez Gene ID
UniProt ID

Product Background


Gene summary
EHMT2 (Euchromatic Histone-Lysine N-Methyltransferase 2) is a Protein Coding gene. Diseases associated with EHMT2 include choline deficiency disease. Among its related pathways are Gene Expression and Cellular Senescence. GO annotations related to this gene include p53 binding and C2H2 zinc finger domain binding. An important paralog of this gene is EHMT1. This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants.
Pathway
Gene Expression, organism-specific biosystem; Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; RNA Polymerase I Promoter Clearance, organism-specific biosystem; RNA Polymerase I Transcription, organism-specific biosystem; RNA Polymerase I Transcription Initiation, organism-specific biosystem; RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Wang, SJ; Liu, WJ; et al. Association of multi-pathogenic infections with BAT2, CXCL12, Mx1 and EHMT2 variations in pigs. MOLECULAR BIOLOGY REPORTS 39:8169-8176(2012).
Delic, D; Ellinger-Ziegelbauer, H; et al. Testosterone response of hepatic gene expression in female mice having acquired testosterone-unresponsive immunity to Plasmodium chabaudi malaria. STEROIDS 76:1204-1212(2011).

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