Anti-EHMT1 (aa 1-100) polyclonal antibody

Species Reactivity

Human

Immunogen

EHMT1 (NP_079033, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. The sequence is MAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGTNTLTRI AENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPA

Conjugate

Alternative Names

EHMT1; euchromatic histone-lysine N-methyltransferase 1; GLP; GLP1; KMT1D; FP13812; EUHMTASE1; Eu-HMTase1; bA188C12.1; histone-lysine N-methyltransferase EHMT1; H3-K9-HMTase 5; G9a-like protein 1; lysine N-methyltransferase 1D; histone H3-K9 methyltransfe

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants.

Pathway

Cellular Senescence; Lysine degradation;