Anti-EFNA1 monoclonal antibody, clone FQS2897(3)

Antibody Isotype

IgG

Clone

FQS2897(3)

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within Human Ephrin A1.

Conjugate

Application Notes

WB: 1/1000 - 1/10000.

Alternative Names

EFNA1; ephrin-A1; EPLG1, TNFAIP4; ECKLG; LERK1; TNF alpha-induced protein 4; ligand of eph-related kinase 1; immediate early response protein B61; eph-related receptor tyrosine kinase ligand 1; tumor necrosis factor alpha-induced protein 4; tumor necrosis

Entrez Gene ID

UniProt ID

Antigen Description

Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cones.

Pathway

Arf6 signaling events, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; EPHA forward signaling, organism-specific biosystem; EPHA2 forward signaling, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem;