Epstein-Barr virus is a member of the herpesvirus family and one of the most common human viruses. The envelope glycoprotein Gp340/Gp220 is the most abundant vomponent of the viral envelope and is believed to be responsible for EBV binding to CR2 receptor on human B-Cells. The Epstein–Barrvirus (EBV), also called human herpesvirus 4 (HHV-4), is a virus of theherpes family, which includes herpes simplex virus 1 and 2, and is one of themost common viruses in humans. It is best known as the cause of infectiousmononucleosis. It is also associated with particular forms of cancer,particularly Hodgkin"s lymphoma, Burkitt"s lymphoma, nasopharyngealcarcinoma, and central nervous system lymphomas associated with HIV. Finally,there is evidence that infection with the virus is associated with a higher riskof certain autoimmune diseases, especially dermatomyositis, systemic lupuserythematosus, rheumatoid arthritis, Sjögren"s syndrome, and multiplesclerosis. Suitable for use in IFA and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.