Anti-SAP47 monoclonal antibody (DMAB9218)

Mouse anti-drosophila SAP47 monoclonal antibody for IP, WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
nb200
Species Reactivity
drosophila
Immunogen
Drosophila synapse associated protein 47 kDa (SAP47) from brain homogenate.
Conjugate
Unconjugated

Target


Alternative Names
SAP47; synapse-associated protein of 47 kDa; synapse associated protein 47 kDa

Product Background


Antigen Description
The "synapse-associated protein of 47 kDa" (SAP47) of Drosophila melanogaster was discovered as the first member of a novel conserved protein family of unknown function. In-situ hybridization and immunostaining using a monoclonal antibody (MAB nc46) showed prominent expression of the Sap47 gene in the nervous system and the specific localisation of the gene product in synaptic terminals. Cross-reacting proteins of similar size were found in several insect species. The SAP47 protein does not contain any domains defined by Prosite patterns that could be indicative of a specific function or molecular interaction. However, by an iterative search of the protein database a novel domain named BSD was identified due to weak but significant amino acid similarity between numerous proteins including BTF2-like transcription factors, synapse associated proteins (SAP47), and DOS2-like proteins.

Citations


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References


Hofbauer, A; Ebel, T; et al. The Wuerzburg Hybridoma Library against Drosophila Brain. JOURNAL OF NEUROGENETICS 23:78-91(2009).
REICHMUTH, C; BECKER, S; et al. THE SAP47 GENE OF DROSOPHILA-MELANOGASTER CODES FOR A NOVEL CONSERVED NEURONAL PROTEIN ASSOCIATED WITH SYNAPTIC TERMINALS. MOLECULAR BRAIN RESEARCH 32:45-54(1995).

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