Anti-RELN monoclonal antibody (DMAB9519MC)

Mouse anti-Chicken RELN monoclonal antibody for IHC, IP Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
TB5
Species Reactivity
Chicken
Immunogen
Crude extract of chicken optic tecta from chicken optic tectum
Conjugate
Unconjugated

Target


Alternative Names
RELN; reelin; reelin, extracellular
Entrez Gene ID

Product Background


Gene summary
RELN (Reelin) is a Protein Coding gene. Diseases associated with RELN include lissencephaly 2 and epilepsy, familial temporal lobe, 7. Among its related pathways are Lissencephaly gene (LIS1) in neuronal migration and development and Guidance Cues and Growth Cone Motility. GO annotations related to this gene include serine-type peptidase activity and very-low-density lipoprotein particle receptor binding. This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.
Pathway
ECM-receptor interaction; Focal adhesion.

Citations


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References


Zheng, J; Long, KB; et al. Genomic characterization and expression of mouse prestin, the motor protein of outer hair cells. MAMMALIAN GENOME 14:87-96(2003).
deBergeyck, V; Nakajima, K; et al. A truncated Reelin protein is produced but not secreted in the 'Orleans' reeler mutation (Reln(rl-Orl)). MOLECULAR BRAIN RESEARCH 50:85-90(1997).

Custom Antibody Labeling


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