Anti-RELN monoclonal antibody (DMAB9519MC)

Mouse anti-Chicken RELN monoclonal antibody for IHC, IP Datasheet

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Host Species
Antibody Isotype
Species Reactivity
Crude extract of chicken optic tecta from chicken optic tectum


Alternative Names
RELN; reelin; reelin, extracellular
Entrez Gene ID

Product Background

Gene summary
RELN (Reelin) is a Protein Coding gene. Diseases associated with RELN include lissencephaly 2 and epilepsy, familial temporal lobe, 7. Among its related pathways are Lissencephaly gene (LIS1) in neuronal migration and development and Guidance Cues and Growth Cone Motility. GO annotations related to this gene include serine-type peptidase activity and very-low-density lipoprotein particle receptor binding. This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.
ECM-receptor interaction; Focal adhesion.


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Goldowitz, D; Cushing, RC; et al. Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin. JOURNAL OF NEUROSCIENCE 17:8767-8777(1997).
Gonzalez, JL; Russo, CJ; et al. Birthdate and cell marker analysis of scrambler: A novel mutation affecting cortical development with a reeler-like phenotype. JOURNAL OF NEUROSCIENCE 17:9204-9211(1997).

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