Anti-MBl monoclonal antibody (DMAB8410MD)
Mouse anti-Drosophila MBl monoclonal antibody for IF, ICC, WB
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Human, Mouse, Rat
Muscleblind was originally isolated following studies of Drosophila, since inactivation of the muscleblind (mbl) gene in this species resulted in defects the development of muscles and the visual system. The Drosophila Muscleblind protein contains 4 so ca
For immunofluorescence use DMAB8410MD diluted 1/50 to 1/250. For immunocytochemistry with ABC or other enzymatic methods use DMAB8410MD at dilutions of 1:1,000. For western blots try DMAB8410MD at dilutions of 1/1,000 to 1/5,000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
muscleblind; mbl; CG10941; CG14477; CG33197; chaste
The muscleblind (MBNL) protein family has been implicated in myotonic dystrophy (DM), but a specific function for these proteins has not been reported. MBNL proteins regulate alternative splicing of two pre-mRNAs that are misregulated in DM, cardiac troponin T (cTNT) and insulin receptor (IR). The function about MBl antigen include DNA binding; nucleic acid binding; nucleic acid binding; zinc ion binding.
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Huang, H; Wahlin, KJ; et al. Developmental regulation of muscleblind-like (MBNL) gene expression in the chicken embryo retina. DEVELOPMENTAL DYNAMICS 237:286-296(2008).
Pascual, M; Monferrer, L; et al. A GFP-tagged Muscleblind C protein isoform reporter construct. FLY 4:333-337(2010).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.