Anti-MBl monoclonal antibody (DMAB8410MD)

Mouse anti-Drosophila MBl monoclonal antibody for IF, ICC, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
A52O52
Species Reactivity
Human, Mouse, Rat
Immunogen
Muscleblind was originally isolated following studies of Drosophila, since inactivation of the muscleblind (mbl) gene in this species resulted in defects the development of muscles and the visual system. The Drosophila Muscleblind protein contains 4 so ca
Conjugate
Unconjugated

Applications


Application Notes
For immunofluorescence use DMAB8410MD diluted 1/50 to 1/250. For immunocytochemistry with ABC or other enzymatic methods use DMAB8410MD at dilutions of 1:1,000. For western blots try DMAB8410MD at dilutions of 1/1,000 to 1/5,000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
muscleblind; mbl; CG10941; CG14477; CG33197; chaste
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
The muscleblind (MBNL) protein family has been implicated in myotonic dystrophy (DM), but a specific function for these proteins has not been reported. MBNL proteins regulate alternative splicing of two pre-mRNAs that are misregulated in DM, cardiac troponin T (cTNT) and insulin receptor (IR). The function about MBl antigen include DNA binding; nucleic acid binding; nucleic acid binding; zinc ion binding.

Citations


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References


Chung, RT; Gordon, FD; et al. Human Monoclonal Antibody MBL-HCV1 Delays HCV Viral Rebound Following Liver Transplantation: A Randomized Controlled Study. AMERICAN JOURNAL OF TRANSPLANTATION 13:1047-1054(2013).
Ip, WKE; Chan, KH; et al. Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection. JOURNAL OF INFECTIOUS DISEASES 191:1697-1704(2005).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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