Anti-Csp monoclonal antibody (DMAB9166MD)

Mouse anti-drosophila Csp monoclonal antibody for IP, WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
JB3
Species Reactivity
drosophila
Immunogen
purified bacterially expressed Drosophila CSP-GST fusion protein (cysteine string protein-glutathione-S-transferase).
Conjugate
Unconjugated

Target


Alternative Names
Csp; Cysteine string protein; ab49; anon-WO02059370.50; CG6395; csp
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DNAJC5 (DnaJ Heat Shock Protein Family (Hsp40) Member C5) is a Protein Coding gene. Diseases associated with DNAJC5 include ceroid lipofuscinosis, neuronal, 4, parry type and cln4 disease. Among its related pathways are Neurotransmitter Release Cycle and Transmission across Chemical Synapses. GO annotations related to this gene include glycoprotein binding and ATP-dependent protein binding. An important paralog of this gene is DNAJB7. This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8.
Antigen Description
DnaJ homolog subfamily C member 5, also known as cysteine string protein or CSP is a protein, that in humans encoded by the DNAJC5 gene. It was first described in 1990. Ceroid lipofuscinosis, neuronal, 4B (CLN4B) [MIM:162350]: An adult-onset neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. CLN4B has no visual involvement and is characterized by seizures and other neurologic symptoms. Note=The disease is caused by mutations affecting the gene represented in this entry. The encoded protein is a member of the J protein family. These proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins (Hsp70). DNAJC5 is a guanine nucleotide exchange factor for Gα proteins. CSPα plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. It is known to play a role in cystic fibrosis and Huntingtons disease.
Pathway
Protein processing in endoplasmic reticulum.

Citations


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References


WHITE, KL; JARBOE, DL; et al. IMMUNIZATION WITH IRRADIATED PLASMODIUM-BERGHEI SPOROZOITES INDUCES IL-2 AND IFN-GAMMA BUT NOT IL-4. PARASITE IMMUNOLOGY 16:479-491(1994).
Villamarin-Vazquez, JL; Chiva-Nebot, F; et al. Seroprevalence of brucellosis in agricultural workers living in coastal areas of Castellon, Spain. SALUD PUBLICA DE MEXICO 44:137-139(2002).

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