Rabbit anti-Human Drosha polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide, corresponding to amino acids 800-850 of Human Drosha

Conjugate

Alternative Names

DROSHA; drosha, ribonuclease type III; ribonuclease type III, nuclear; RNASEN; ribonuclease 3; drosha; double stranded RNA specific endoribonuclease; ribonuclease type III; Etohi2; HSA242976; RN3; RNASE3L; p241; RNase III; protein Drosha; nuclear RNase II

Entrez Gene ID

UniProt ID

Antigen Description

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3 and 5 strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Pathway

Direct p53 effectors; Gene Expression; MicroRNA (miRNA) Biogenesis; Regulatory RNA pathways; Ribosome biogenesis in eukaryotes;