Anti-DYNC1LI1 monoclonal antibody, clone FQS22351

Antibody Isotype

IgG

Clone

FQS22351

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment corresponding to residues in Human Cytoplasmic dynein 1 light intermediate chain 1 (UniProt Q9Y6G9).

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250; ICC/IF: 1/100 - 1/250; IP: 1/10 - 1/100.

Alternative Names

DYNC1LI1; dynein, cytoplasmic 1, light intermediate chain 1; DNCLI1, dynein, cytoplasmic, light intermediate polypeptide 1; cytoplasmic dynein 1 light intermediate chain 1; DLC-A; dynein light chain A; dynein light chain-A; dynein light intermediate chai

Entrez Gene ID

UniProt ID

Antigen Description

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.

Pathway

Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Salmonella infection, organism-specific biosystem; Salmonella infection, conserved biosystem; Vasopressin-regulated water reabsorption, organism-specific biosystem; Vasopressin-regulated water reabsorption, conserved biosystem;