Anti-DTNBP1 monoclonal antibody, clone FQS8152

Antibody Isotype

IgG

Clone

FQS8152

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to a region within Human Dysbindin (UniProt: Q96EV8).

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250; ICC: 1/100 - 1/250; IP: 1/10 - 1/100; Flow Cyt: 1/100 - 1/500.

Alternative Names

DTNBP1; dystrobrevin binding protein 1; dysbindin; DBND; Dysbindin; HPS7; My031; dysbindin-1; hermansky-Pudlak syndrome 7 protein; SDY; FLJ30031; MGC20210; DKFZp564K192;

Entrez Gene ID

UniProt ID

Antigen Description

The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation.

Pathway

Clathrin derived vesicle budding, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; trans-Golgi Network Vesicle Budding, organism-specific biosystem;