Anti-DPH5 monoclonal antibody (DCABH-11319) Made to order

Rabbit anti-Human DPH5 monoclonal antibody for WB, ELISA

View other DPH5 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DPH5 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DPH5; DPH5 homolog (S. cerevisiae); diphthine synthase; CGI 30; protein x 0011; diphthamide biosynthesis methyltransferase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DPH5 (Diphthamide Biosynthesis 5) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include methyltransferase activity and diphthine synthase activity. This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. Diphthine synthase is an enzyme that in humans is encoded by the DPH5 gene. 0The function about DPH5 antigen include diphthine synthase activity; diphthine synthase activity; methyltransferase activity; transferase activity.
Pathway
diphthamide biosynthesis, organism-specific biosystem.

Citations


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References


Lim, D; Gondro, C; et al. Identification of Recently Selected Mutations Driven by Artificial Selection in Hanwoo (Korean Cattle). ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 26:603-608(2013).
MATTHEAKIS, LC; SHEN, WH; et al. DPH5, A METHYLTRANSFERASE GENE REQUIRED FOR DIPHTHAMIDE BIOSYNTHESIS IN SACCHAROMYCES-CEREVISIAE. MOLECULAR AND CELLULAR BIOLOGY 12:4026-4037(1992).

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