Anti-Human DOK1 polyclonal antibody (DCABH-4567)

Rabbit Anti-Human DOK1 polyclonal antibody for IHC-P Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to N-terminus of human DOK-1 protein.
Conjugate
Unconjugated

Data Examples


Human Breast Carcinoma stained with anti-DOK-1 antibody

Target


Alternative Names
DOK1; docking protein 1, 62kDa (downstream of tyrosine kinase 1) ; P62DOK; docking protein 1; pp62; p62 (dok)
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DOK1 (Docking Protein 1) is a Protein Coding gene. Diseases associated with DOK1 include leukemia, chronic myeloid, somatic. Among its related pathways are Signaling by GPCR and Kit Receptor Signaling Pathway. GO annotations related to this gene include receptor signaling protein activity and insulin receptor binding. An important paralog of this gene is DOK5. The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene.
Antigen Description
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. Docking protein 1 is a protein that in humans is encoded by the DOK1 gene. Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. The function about DOK1 antigen include insulin receptor binding; receptor signaling protein activity.

Citations


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References


Cao, XQ; Tanis, KQ; et al. Enhancement of ABL Kinase Catalytic Efficiency by a Direct Binding Regulator Is Independent of Other Regulatory Mechanisms. JOURNAL OF BIOLOGICAL CHEMISTRY 283:31401-31407(2008).
Saulnier, A; Vaissiere, T; et al. Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers. INTERNATIONAL JOURNAL OF CANCER 130:2484-2494(2012).

Custom Antibody Labeling


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