Anti-DNMT1 monoclonal antibody [Biotin]

Antibody Isotype

IgG1

Clone

71C2331.2

Species Reactivity

Mouse, Human, Zebrafish

Immunogen

Synthetic peptide corresponding to Human Dnmt1 aa 637-650. NCBI Accession No. NP_001370Sequence: EKDDREDKENAFKR Database link: P26358

Conjugate

Biotin

Application Notes

WB: 2 - 4 μg/ml; IHC-P: 1 - 2 μg/ml; IHC-Fr: 1 - 2 μg/ml;

Alternative Names

DNMT1; DNA (cytosine-5-)-methyltransferase 1; DNMT; DNA (cytosine-5)-methyltransferase 1; CXXC9; MCMT; m.HsaI; DNA MTase HsaI; CXXC finger protein 9; DNA methyltransferase 1; DNA methyltransferase HsaI; CXXC-type zinc finger protein 9; AIM; HSN1E; FLJ1629

Entrez Gene ID

1786

UniProt ID

I6L9H2

Antigen Description

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

Pathway

Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Methionine degradation, organism-specific biosystem; Methionine degradation, conserved biosystem; One Carbon Metabolism, organism-specific biosystem; Regulation of retinoblastoma protein, organism-specific biosystem;