Anti-DMPO Nitrone Adduct monoclonal antibody (DMAB8088)

Mouse anti-DMPO Nitrone Adduct monoclonal antibody for ICC/IHC, IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
M1665B
Species Reactivity
N/A
Immunogen
5,5-dimethyl-2-(8-octanoic acid)-1-pyrrolone-N-oxide conjugated to Ovalbumin.
Conjugate
Unconjugated

Target


Alternative Names
55 dimethyl 1 pyrroline N oxide nitrone adduct; DMPO Nitrone Adduct; 5,5-dimethyl-1-pyrroline N-oxide; DMPO; 5,5-DIMETHYL-1-PYRROLINE N-OXIDE; 2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRROLE 1-OXIDE
3,4-DIHYDRO-2,2-DIMETHYL-2H-PYRROLE 1-OXIDE

Product Background


Antigen Description
The formation of free radicals and other highly reactive oxygen species has been implicated in the pathogenesis of many disease states. The ability to identify these species is crucial, and spin trapping has accomplished this goal. DMPO (5,5-dimethyl-1-pyrroline N-oxide) is one of the least toxic to cells and animals, and possesses convenient pharmacokinetics (uptake, distribution, metabolism and excretion) in biological systems. Recent studies have determined that nitric oxide may substantially affect the quantitative determination of DMPO adducts, and therefore extra caution is required when studying generation of these species in the presence of nitric oxide or its radicals. DMPO adducts can be generated with protein and DNA radicals.

Citations


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References


Saxena, P; Saxena, AK; et al. Transition metal-catalyzed. oxidation of ascorbate in human cataract extracts: Possible role of advanced glycation end products. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 41:1473-1481(2000).
Detweiler, CD; Deterding, LJ; et al. Immunological identification of the heart myoglobin radical formed by hydrogen peroxide. FREE RADICAL BIOLOGY AND MEDICINE 33:364-369(2002).

Custom Antibody Labeling


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