Anti-DIO1 monoclonal antibody (DCABH-11282) Made to order

Rabbit anti-Human DIO1 monoclonal antibody for WB, ELISA

View other DIO1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DIO1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DIO1; deiodinase, iodothyronine, type I; TXDI1; type I iodothyronine deiodinase; DIOI; type 1 DI
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DIO1 (Deiodinase, Iodothyronine Type I) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include selenium binding and thyroxine 5-deiodinase activity. An important paralog of this gene is DIO3. The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) by 5'-deiodination to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3), which is essential for growth, differentiation and basal metabolism in vertebrates. It is expressed predominantly in liver and kidney and provides most of the circulating T3. This protein contains a selenocysteine (Sec) residue at its active site that is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
Antigen Description
The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3,5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. Responsible for the deiodination of T4 (3,5,3,5-tetraiodothyronine) into T3 (3,5,3-triiodothyronine) and of T3 into T2 (3,3-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. The function about DIO1 antigen include selenium binding; thyroxine 5-deiodinase activity.
Pathway
Amine-derived hormones, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Regulation of thyroid hormone activity, organism-specific biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem; Selenium Pathway, organism-specific biosystem; Thyroxine biosynthesis, organism-specific biosystem.

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References


Kohrle, J; Gartner, R; et al. Selenium and thyroid. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM 23:815-827(2009).
Matsumoto, C; Ito, M; et al. Genes that characterize T-3-predominant Graves' thyroid tissues. EUROPEAN JOURNAL OF ENDOCRINOLOGY 168:137-144(2013).

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