Anti-DICER1 monoclonal antibody, clone T278-8

Antibody Isotype

IgG1

Clone

T278-8

Species Reactivity

Mouse; Rat; Human

Immunogen

Fusion protein, corresponding to C terminal amino acids 1638-1899 of Mouse Dicer (Q8R418).

Conjugate

Application Notes

WB: 1 μg/ml;

Alternative Names

DICER1; Dicer1, Dcr-1 homolog (Drosophila); endoribonuclease Dicer; double-strand-specific ribonuclease mDCR-1; D12Ertd7e; mKIAA0928; 1110006F08Rik;

Entrez Gene ID

UniProt ID

Antigen Description

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.

Pathway

Gene Expression, organism-specific biosystem; MicroRNA (miRNA) Biogenesis, organism-specific biosystem; Regulatory RNA pathways, organism-specific biosystem; Small Interfering RNA (siRNA) Biogenesis, organism-specific biosystem; mRNA processing, organism-specific biosystem;