Anti-DHDH monoclonal antibody (DCABH-11272) Made to order

Rabbit anti-Human DHDH monoclonal antibody for WB, ELISA

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DHDH is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DHDH; dihydrodiol dehydrogenase (dimeric); trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; HUM2DD; D-xylose 1-dehydrogenase; 3-deoxyglucosone reductase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DHDH (Dihydrodiol Dehydrogenase) is a Protein Coding gene. Diseases associated with DHDH include lung cancer. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Porphyrin and chlorophyll metabolism. GO annotations related to this gene include oxidoreductase activity and trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity. This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction.
Antigen Description
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. Protein Symbol:Q9UQ10-DHDH_HUMANRecommended name:Trans-1,2-dihydrobenzene-1,2-diol dehydrogenaseProtein Accession:Q9UQ10The function about DHDH antigen include D-xylose 1-dehydrogenase (NADP+) activity; NAD(P)+ transhydrogenase activity; electron carrier activity; nucleotide binding; oxidoreductase activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity.
Pathway
Metabolism of xenobiotics by cytochrome P45, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P45, conserved biosystem; Pentose and glucuronate interconversions, organism-specific biosystem; Pentose and glucuronate interconversions, conserved biosystem.

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References


SHINODA, M; HARA, A; et al. INHIBITION OF DIMERIC DIHYDRODIOL DEHYDROGENASE BY 4-HYDROXYPHENYLKETONE DERIVATIVES - ASPECTS OF INHIBITOR STRUCTURE AND BINDING-SPECIFICITY. JOURNAL OF BIOCHEMISTRY 112:840-844(1992).
El-Kabbani, O; Chung, RPT; et al. Crystallization and preliminary X-ray diffraction analysis of monkey dimeric dihydrodiol dehydrogenase. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 58:163-164(2002).

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