Anti-DHDDS monoclonal antibody (DCABH-11271) Made to order

Rabbit anti-Human DHDDS monoclonal antibody for WB, ELISA

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DHDDS is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DHDDS; dehydrodolichyl diphosphate synthase; DS; FLJ13102; HDS; dedol-PP synthase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DHDDS (Dehydrodolichyl Diphosphate Synthase Subunit) is a Protein Coding gene. Diseases associated with DHDDS include retinitis pigmentosa 59 and dhdds-related retinitis pigmentosa. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include transferase activity, transferring alkyl or aryl (other than methyl) groups. The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Antigen Description
Dehydrodolichyl diphosphate (dedol-PP) synthase catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Retinitis pigmentosa 59 (RP59) [MIM:613861]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Note=The disease is caused by mutations affecting the gene represented in this entry. Dehydrodolichyl diphosphate synthase is an enzyme that in humans is encoded by the DHDDS gene. The function about DHDDS antigen include protein binding; transferase activity, transferring alkyl or aryl (other than methyl) groups.
Pathway
Terpenoid backbone biosynthesis, organism-specific biosystem; Terpenoid backbone biosynthesis, conserved biosystem; dolichol and dolichyl phosphate biosynthesis, organism-specific biosystem.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Zelinger, L; Banin, E; et al. A Missense Mutation in DHDDS, Encoding Dehydrodolichyl Diphosphate Synthase, Is Associated with Autosomal-Recessive Retinitis Pigmentosa in Ashkenazi Jews. AMERICAN JOURNAL OF HUMAN GENETICS 88:207-215(2011).

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