Anti-DEDD2 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human DEDD2 is used for rabbit immunization.

Conjugate

Alternative Names

DEDD2; death effector domain containing 2; DNA-binding death effector domain-containing protein 2; FLAME 3; DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3; death effector domain-containing DNA binding protein 2; FLAME-3;

Entrez Gene ID

UniProt ID

Antigen Description

Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.