DDHD1 (DDHD domain containing 1) is a protein-coding gene. Diseases associated with DDHD1 include autosomal recessive spastic paraplegia type 28, and paraplegia. GO annotations related to this gene include hydrolase activity and metal ion binding. An important paralog of this gene is DDHD2. Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity
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