DAO (NP_001908, 119 a.a. ~ 218 a.a) partial recombinant protein with GST tag. The sequence is PRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVI VNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHD
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.
Pathway
Arginine and proline metabolism; D-Arginine and D-ornithine metabolism; Glycine, serine and threonine metabolism; Glyoxylate metabolism
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