Anti-D. discoideum ACTN Monoclonal antibody (DMAB9433)

Mouse Anti-D. discoideum ACTN Monoclonal antibody for WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Species Reactivity
D. discoideum
Immunogen
alpha actinin.
Conjugate
Unconjugated

Target


Alternative Names
alpha actinin; Actinin alpha 1; ACTN 1; Alpha Actinin 1; Alpha actinin cytoskeletal isoform; Alpha-actinin-1

Product Background


Antigen Description
Alpha-catenin was suggested to function as a linking protein between cadherins and actin-containing filaments of the cytoskeleton. It has been reported that the actin binding proteins vinculin and alpha-actinin can bind to alpha-catenin. However, a protein complex including a cadherin, actin, beta-catenin and alpha-catenin has not been isolated. It has been suggested that alpha-catenin does not bind with high affinity to both actin filaments and the E-cadherin-beta-catenin complex at the same time. It has been observed that when alpha-catenin is not in a molecular complex with beta-catenin, it dimerizes and functions to regulate actin filament assembly, possibly by competing with Arp2/3 protein.

Citations


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References


Tachikawa, E; Itho, K; et al. Effects of interferons on cortisol production in bovine adrenal fasciculata cells stimulated by adrenocorticotropin. JOURNAL OF PHARMACY AND PHARMACOLOGY 51:465-473(1999).
Bridger, PS; Haupt, S; et al. Integrin activation in bovine placentomes and in caruncular epithelial cells isolated from pregnant cows. BIOLOGY OF REPRODUCTION 79:274-282(2008).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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