Anti-Cytochrome P450 1A1 + 1A2 monoclonal antibody (DCABH-333)

Mouse anti-Rat Cytochrome P450 1A1 + 1A2 monoclonal antibody for WB, IHC-P, ICC/IF Datasheet

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Host Species
Antibody Isotype
Species Reactivity
Mouse, Human
3-methylcholanthrene induced Rat Cytochrome P450 1A1 + 1A2.


Application Notes
WB: 1/500; IHC-P: 1/50 - 1/200; ICC/IF: 1/20 - 1/200;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.


Alternative Names
CYP1A1; cytochrome P450, family 1, subfamily a, polypeptide 1; cytochrome P450 1A1; CYPIA1; P450MT2; P450form6
Entrez Gene ID
UniProt ID

Product Background

Antigen Description
Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P450s are membrane-bound, either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells where they metabolise thousands of endogenous and exogenous compounds. In the liver, these substrates include toxins, drugs, and other unneeded and potentially harmful molecules. Humans have 18 families of cytochrome P450 genes and 43 subfamilies; the CYP1 family is involved in drug metabolism and includes 3 subfamilies, 3 genes and 1 pseudogene. The function about Cytochrome P450 1A1 + 1A2 antigen include aromatase activity; catalytic activity; demethylase activity; electron carrier activity; enzyme binding; enzyme binding; flavonoid 3-monooxygenase activity; heme binding; metal ion binding; monooxygenase activity; monooxygenase activity; oxidoreductase ac.
Biological oxidations, organism-specific biosystem; Cytochrome P45 - arranged by substrate type, organism-specific biosystem; Fatty Acid Omega Oxidation, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P45, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P45, conserved biosystem.


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