Anti-Zeugmatin monoclonal antibody (DMAB9587)
Mouse anti-Chicken Zeugmatin monoclonal antibody for WB, AP, IHC
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Zeugmatin from chicken cardiac muscle.
Zeugmatin is actually part of the Z-Band region of titin and that this region of titin plays an important role in the assembly of the Z-bands and myofibrils. Rhee et al. (1994) reported that during myofibrillogenesis, zeugmatin antibody localization is detected in fully formed Z-bands in the mature myofibrils, in the Z-bodies of the nascent myofibrils, but not in the Z-bodies of the premyofibrils. These observations lead to the suggestion that zeugmatin might be responsible for the fusion of the Z-bodies to form the solid Z-bands of the mature myofibrils. As part of a study to test aspects of this model of myofibrillogenesis, we isolated a 1. 8 kb cDNA from a chicken cardiac expression library using an anti-zeugmatin antibody. We found this chicken cDNA to be 60% identical at the amino acid level to a segment of the Z-band region of human cardiac titin (connectin). This homology along with Western blot analysis with purified titin, suggested that zeugmatin is in fact part of the N-terminal region of chicken titin.
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STROMER, MH; et al. IMMUNOCYTOCHEMISTRY OF THE MUSCLE-CELL CYTOSKELETON. MICROSCOPY RESEARCH AND TECHNIQUE 31:95-105(1995).
RHEE, D; SANGER, JM; et al. THE PREMYOFIBRIL - EVIDENCE FOR ITS ROLE IN MYOFIBRILLOGENESIS. CELL MOTILITY AND THE CYTOSKELETON 28:1-24(1994).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.