Anti-Zeugmatin monoclonal antibody (DMAB9587)

Mouse anti-Chicken Zeugmatin monoclonal antibody for WB, AP, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
20
Species Reactivity
Chicken
Immunogen
Zeugmatin from chicken cardiac muscle.
Conjugate
Unconjugated

Target


Alternative Names
Zeugmatin

Product Background


Antigen Description
Zeugmatin is actually part of the Z-Band region of titin and that this region of titin plays an important role in the assembly of the Z-bands and myofibrils. Rhee et al. (1994) reported that during myofibrillogenesis, zeugmatin antibody localization is detected in fully formed Z-bands in the mature myofibrils, in the Z-bodies of the nascent myofibrils, but not in the Z-bodies of the premyofibrils. These observations lead to the suggestion that zeugmatin might be responsible for the fusion of the Z-bodies to form the solid Z-bands of the mature myofibrils. As part of a study to test aspects of this model of myofibrillogenesis, we isolated a 1. 8 kb cDNA from a chicken cardiac expression library using an anti-zeugmatin antibody. We found this chicken cDNA to be 60% identical at the amino acid level to a segment of the Z-band region of human cardiac titin (connectin). This homology along with Western blot analysis with purified titin, suggested that zeugmatin is in fact part of the N-terminal region of chicken titin.

Citations


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References


RHEE, D; SANGER, JM; et al. THE PREMYOFIBRIL - EVIDENCE FOR ITS ROLE IN MYOFIBRILLOGENESIS. CELL MOTILITY AND THE CYTOSKELETON 28:1-24(1994).
Turnacioglu, KK; Mittal, B; et al. Zeugmatin is part of the Z-band targeting region of titin. CELL STRUCTURE AND FUNCTION 22:73-82(1997).

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