Anti-RAB7A polyclonal antibody (CPBT-56441RC)

Rabbit Anti-Human RAB7A (aa 90-140) polyclonal antibody for ICC/IF, WB, IHC-P Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Rat, Chicken, Cow, Dog, Human, Xenopus laevis, Chimpanzee, Monkey, Zebrafish
Immunogen
Synthetic peptide, corresponding to a portion of the amino acids 90-140 of Human RAB7A
Conjugate
Unconjugated

Applications


Application Notes
WB: 0.5 - 1μg/ml; IHC-P: 10μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
RAB7A; RAB7A, member RAS oncogene family; ras-related protein Rab-7a; MGC16212; CMT2B; Member RAS oncogene family
Entrez Gene ID
UniProt ID

Product Background


Gene summary
RAB7A (RAB7A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB7A include charcot-marie-tooth disease, type 2b and choroideremia. Among its related pathways are Immune System and Endocytosis. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB7B. RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
Antigen Description
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulateCharcot-Marie-Tooth disease 2B (CMT2B) [MIM:600882]: A dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Note=The disease is caused by mutations affecting the gene represented in this entry. Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene. Members of the RAB family of RAS-related GTP-binding proteins are important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori.
Pathway
Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Salmonella infection, organism-specific biosystem; Salmonella infection, conserved biosystem.

Citations


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References


Osinska, M; Wiejak, J; et al. Distinct expression, localization and function of two Rab7 proteins encoded by paralogous genes in a free-living model eukaryote. ACTA BIOCHIMICA POLONICA 58:597-607(2011).
Day, PM; Thompson, CD; et al. Identification of a Role for the trans-Golgi Network in Human Papillomavirus 16 Pseudovirus Infection. JOURNAL OF VIROLOGY 87:3862-3870(2013).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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