Anti-alpha Dihydropyridine Receptor monoclonal antibody (DMAB9474)

Mouse anti-Chicken alpha Dihydropyridine Receptor monoclonal antibody for IP, WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
M3F11
Species Reactivity
Chicken
Immunogen
purified α dihydropyridine receptor
Conjugate
Unconjugated

Target


Alternative Names
DHPR; DHP receptor; α dihydropyridine receptor; α DHP receptor

Product Background


Antigen Description
The dihydropyridine (DHP) receptor purified from skeletal muscle comprises five protein subunits (α1, α2, β, γ and δ) and produces Ca2+ currents that are blocked by DHPs1. Cloning of the α1 and α2-subunits, the former affinity-labelled by DHP, has shown that the α1-subunit is expressed in skeletal muscle alone, whereas the α2- and δ-subunits are also expressed in other tissues. Although the transient expression of the α1-subunit in myoblasts from dysgenic mice (but not in oocytes) has been demonstrated, the use of these expression systems to determine the function of the α1-subunit is complicated by the presence of endogenous Ca2+ currents, which may reflect the constitutive expression of proteins similar to the α2-, β-, γ- and/or δ-subunits.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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