Anti-Transient Axonal Glycoprotein-1 monoclonal antibody (DMAB9531)

Mouse anti-Chicken Transient Axonal Glycoprotein-1 monoclonal antibody for IHC, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
23.4-5
Species Reactivity
Chicken
Immunogen
chick spinal cord membranes
Conjugate
Unconjugated

Target


Alternative Names
TAG-1; transient axonal glycoprotein-1

Product Background


Gene summary
CNTN2 (Contactin 2) is a Protein Coding gene. Diseases associated with CNTN2 include epilepsy, myoclonic, familial adult, 5 and benign adult familial myoclonic epilepsy. Among its related pathways are Developmental Biology and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include identical protein binding and glycoprotein binding. An important paralog of this gene is DSCAML1. The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.
Antigen Description
Epilepsy, familial adult myoclonic, 5 (FAME5) [MIM:615400]: A form of cortical myoclonic tremor with epilepsy, a syndrome characterized by cortical myoclonus and variable occurrence of epileptic seizures. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom; both complex partial as well as generalized tonic clonic seizures are described. Some patients exhibit mild cognitive impairment. Note=The disease is caused by mutations affecting the gene represented in this entry. Contactin-2 is a protein that in humans is encoded by the CNTN2 gene. The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. TAG-1 is a neural recognition molecule in the immunoglobulin superfamily that is predominantly expressed in the developing brain. Several lines of evidence suggest that TAG-1 is involved in the outgrowth, guidance, and fasciculation of neurites. The subtle changes in neural plasticity induced by TAG-1 deficiency during development cause the selective vulnerability of specific brain regions and the epileptogenicity in TAG-1 (−/−) mice.

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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