Anti- MNR2 Monoclonal antibody (DMAB9470)

Mouse Anti- MNR2 Monoclonal antibody for IH Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Species Reactivity
Chicken
Immunogen
C terminal - GST fusion protein MNR2 made in E. coli.
Conjugate
Unconjugated

Target


Alternative Names
MNR2; Mnr2

Product Background


Antigen Description
The MNR2 gene encodes a protein closely related to the Alr proteins, but includes conserved features that define a distinct subgroup of CorA proteins in fungal genomes, suggesting a distinct role in Mg2+ homeostasis. Like an alr1 mutant, growth of an mnr2 mutant was sensitive to Mg2+-deficient conditions, but the mnr2 mutant was observed to accumulate more Mg2+ than a wild-type strain under these conditions. These phenotypes suggested that Mnr2 may regulate Mg2+ storage within an intracellular compartment. Consistent with this interpretation, the Mnr2 protein was localized to the membrane of the vacuole, an internal compartment implicated in the storage of excess mineral nutrients by yeast. A direct role of Mnr2 in Mg2+ transport was suggested by the observation that increased Mnr2 expression, which redirected some Mnr2 protein to the cell surface, also suppressed the Mg2+-requirement of an alr1 alr2 double mutant strain.

Citations


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References


Arber, S; Han, B; et al. Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. NEURON 23:659-674(1999).
Gimenez, CM; Alvarez, JMA; et al. Inheritance of resistance to systemic symptom expression of Melon necrotic spot virus (MNSV) in Cucumis melo L. 'Doublon'. EUPHYTICA 134:319-324(2003).

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