Anti- MNR2 Monoclonal antibody (DMAB9470)

Mouse Anti- MNR2 Monoclonal antibody for IH Datasheet

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Host Species
Antibody Isotype
Species Reactivity
C terminal - GST fusion protein MNR2 made in E. coli.


Alternative Names
MNR2; Mnr2

Product Background

Antigen Description
The MNR2 gene encodes a protein closely related to the Alr proteins, but includes conserved features that define a distinct subgroup of CorA proteins in fungal genomes, suggesting a distinct role in Mg2+ homeostasis. Like an alr1 mutant, growth of an mnr2 mutant was sensitive to Mg2+-deficient conditions, but the mnr2 mutant was observed to accumulate more Mg2+ than a wild-type strain under these conditions. These phenotypes suggested that Mnr2 may regulate Mg2+ storage within an intracellular compartment. Consistent with this interpretation, the Mnr2 protein was localized to the membrane of the vacuole, an internal compartment implicated in the storage of excess mineral nutrients by yeast. A direct role of Mnr2 in Mg2+ transport was suggested by the observation that increased Mnr2 expression, which redirected some Mnr2 protein to the cell surface, also suppressed the Mg2+-requirement of an alr1 alr2 double mutant strain.


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Tanabe, Y; William, C; et al. Specification of motor neuron identity by the MNR2 homeodomain protein. CELL 95:67-80(1998).
Odden, JP; Holbrook, S; et al. Drosophila HB9 is expressed in a subset of motoneurons and interneurons, where it regulates gene expression and axon pathfinding. JOURNAL OF NEUROSCIENCE 22:9143-9149(2002).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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