Anti-CDKN2A monoclonal antibody, clone 6-D4

Antibody Isotype

IgG2b

Clone

6-D4

Species Reactivity

Mouse

Immunogen

Synthetic peptide corresponding to Mouse CDKN2A/p19ARF conjugated to Keyhole Limpet Haemocyanin (KLH).

Conjugate

Application Notes

WB: 1 μg/ml; IHC-P: 5 μg/ml;

Alternative Names

CDKN2A; cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A, isoform 3; CDK4I; p16-INK4; p16-INK4a; mitochondrial smARF; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor protein; cyclin-dependent kinase inhib

Entrez Gene ID

UniProt ID

Antigen Description

The gene for CDK2NA generates several transcripts/proteins which differ from each other in their first exons. Three of these transcripts are generated by alternative splicing (isoform 1 a.k.a p16INK4A, isoform 2 and isoform 3 a.k.a p12), two of which are known to function as inhibitors of CDK4 kinase. One other transcript that is generated from this gene contains an alternate reading frame (ARF), with the first exon located 20kb upstream of the remainder of the gene(isoform 4 a.k.a. p14ARF, p19ARF, ARF). In spite of the structural and some functional differences, all the proteins encoded by the CDKN2A gene are involved in cell cycle G1 control.

Pathway

Apoptosis, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem;