Anti-CYP4V2 monoclonal antibody (DCABH-11204) Made to order

Rabbit anti-Human CYP4V2 monoclonal antibody for WB, ELISA

View other CYP4V2 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CYP4V2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CYP4V2; cytochrome P450, family 4, subfamily V, polypeptide 2; cytochrome P450 4V2; CYP4AH1; BCD; FLJ18432
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CYP4V2 (Cytochrome P450 Family 4 Subfamily V Member 2) is a Protein Coding gene. Diseases associated with CYP4V2 include bietti crystalline corneoretinal dystrophy and corneal dystrophy. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8. This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy.
Antigen Description
This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy. Bietti crystalline corneoretinal dystrophy (BCD) [MIM:210370]: An autosomal recessive ocular disease characterized by retinal degeneration and marginal corneal dystrophy. Typical features include multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most patients have similar crystals at the corneoscleral limbus. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, they develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life. Note=The disease is caused by mutations affecting the gene represented in this entry. Cytochrome P450 4V2 is a protein that in humans is encoded by the CYP4V2 gene. 0The function about CYP4V2 antigen include electron carrier activity; heme binding; metal ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Yin, HF; Jin, CF; et al. Molecular Analysis and Phenotypic Study in 14 Chinese Families with Bietti Crystalline Dystrophy. PLOS ONE 9:-(2014).
Haddad, NMN; Waked, N; et al. Clinical and molecular findings in three Lebanese families with Bietti crystalline dystrophy: Report on a novel mutation. MOLECULAR VISION 18:1182-1188(2012).

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