Anti-CYP3A43 monoclonal antibody (DCABH-11198) Made to order

Rabbit anti-Human CYP3A43 monoclonal antibody for WB, ELISA

View other CYP3A43 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CYP3A43 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CYP3A43; cytochrome P450, family 3, subfamily A, polypeptide 43; cytochrome P450, subfamily IIIA, polypeptide 43; cytochrome P450 3A43; cytochrome P450 polypeptide 43; MGC119315
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CYP3A43 (Cytochrome P450 Family 3 Subfamily A Member 43) is a Protein Coding gene. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21. 1. Alternate splicing results in multiple transcript variants encoding different isoforms.
Antigen Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21. 1. Alternate splicing of this gene results in three transcript variants encoding different isoforms. Exhibits low testosterone 6-beta-hydroxylase activity. Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene. 0The function about CYP3A43 antigen include aromatase activity; electron carrier activity; heme binding; metal ion binding; monooxygenase activity; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.
Pathway
Biological oxidations, organism-specific biosystem; Cytochrome P45 - arranged by substrate type, organism-specific biosystem; Drug metabolism - cytochrome P45, organism-specific biosystem; Drug metabolism - cytochrome P45, conserved biosystem; Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Linoleic acid metabolism, organism-specific biosystem.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Westlind-Johnsson, A; Malmebo, S; et al. Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. DRUG METABOLISM AND DISPOSITION 31:755-761(2003).

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