Anti-CYP2D5 polyclonal antibody (DPABH-29175)

Specifications


Host Species
Goat
Antibody Isotype
IgG
Species Reactivity
Rat
Immunogen
Synthetic peptide: CDAFTAQNGRSINPK, corresponding to internal sequence amino acids 164-178 of Rat Cytochrome P450 2D10 (NP_775426.1).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1 - 3μg/ml;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CYP2D5; cytochrome P450, family 2, subfamily d, polypeptide 5; Cyp2d10; cytochrome P450 2D10; CYPIID10; P450-DB5
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The function about CYP2D5 antigen include aromatase activity; heme binding; iron ion binding; monooxygenase activity.
Pathway
Biological oxidations; Metabolism; Serotonergic synapse; Steroid hormone biosynthesis.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Gilbert, EA; Edwards, RJ; et al. Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon. JOURNAL OF NEURAL TRANSMISSION 110:1091-1101(2003).
Schulz-Utermoehl, T; Bennett, AJ; et al. Polymorphic debrisoquine 4-hydroxylase activity in the rat is due to differences in CYP2D2 expression. PHARMACOGENETICS 9:357-366(1999).

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