Anti-CYP2C19 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide of human CYP2C19 is used for rabbit immunization.

Conjugate

Alternative Names

CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19; CYP2C, cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 19; cytochrome P450 2C19; CPCJ; P450IIC19; CYPIIC17; CYPIIC19; cytochrome P450-11A; cytochrome P450-254C; cytoc

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Pathway

Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Biological oxidations, organism-specific biosystem; Cytochrome P45 - arranged by substrate type, organism-specific biosystem; Drug metabolism - cytochrome P45, organism-specific biosystem; Drug metabolism - cytochrome P45, conserved biosystem; Linoleic acid metabolism, organism-specific biosystem.