Anti-CTRC monoclonal antibody (DCABH-800)

Mouse anti-Human CTRC monoclonal antibody for WB, ELISA, IHC-P, IHC-Fr Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG3
Clone
5F2
Species Reactivity
Human
Immunogen
Purified Human pancreatic Chymotrypsin.
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 5 - 10 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CTRC; chymotrypsin C (caldecrin); chymotrypsin-C; CLCR; ELA4; elastase 4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CTRC (Chymotrypsin C) is a Protein Coding gene. Diseases associated with CTRC include pancreatitis, hereditary and ctrc-related hereditary pancreatitis. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is CELA2B. This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
Antigen Description
Has chymotrypsin-type protease activity and hypocalcemic activity. Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Loss-of-function CTRC variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268). They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased degradation by trypsin (PubMed:22942235). Chymotrypsin C, also known as caldecrin or elastase 4 is an enzyme that in humans is encoded by the CTRC gene. Chymotrypsin C is a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. The function about CTRC antigen include peptidase activity; serine-type endopeptidase activity.

Citations


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References


Nemoda, Z; Sahin-Toth, M; et al. Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen. JOURNAL OF BIOLOGICAL CHEMISTRY 281:11879-11886(2006).
Felderbauer, P; Karakas, E; et al. Multifactorial Genesis of Pancreatitis in Primary Hyperparathyroidism: Evidence for "Protective" (PRSS2) and "Destructive" (CTRC) Genetic Factors. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES 119:26-29(2011).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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