Anti-CTR9 monoclonal antibody (DCABH-11162) Made to order

Rabbit anti-Human CTR9 monoclonal antibody for WB, ELISA

View other CTR9 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CTR9 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CTR9; Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); SH2 domain binding protein 1 (tetratricopeptide repeat containing) , SH2BP1; RNA polymerase-associated protein CTR9 homolog; KIAA0155; p150TSP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CTR9 (CTR9 Homolog, Paf1/RNA Polymerase II Complex Component) is a Protein Coding gene. GO annotations related to this gene include SH2 domain binding and RNA polymerase II core binding. CTR9, parafibromin (CDC73; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al. , 2005 [PubMed 15632063]).
Antigen Description
CTR9, parafibromin (CDC73; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al. , 2005 [PubMed 15632063]). Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and Ser-2- and Ser-5-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 Lys-4 (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of Lys-120 of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3 end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 Lys-4 (H3K4me3) and dimethylation on histone H3 Lys-79 (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 Lys-4 (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). RNA polymerase-associated protein CTR9 homolog is an enzyme that in humans is encoded by the CTR9 gene. 0The function about CTR9 antigen include SH2 domain binding; protein binding.

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References


Abdel-Mohsen, M; Raposo, RAS; et al. Expression profile of host restriction factors in HIV-1 elite controllers. RETROVIROLOGY 10:-(2013).
Zhang, K; Haversat, JM; et al. CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. DEVELOPMENTAL BIOLOGY 383:15-27(2013).

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