Anti-CTNND2 (aa 1081-1190) polyclonal antibody

Species Reactivity

Human

Immunogen

CTNND2 (NP_001323, 1081 a.a. ~ 1190 a.a) partial recombinant protein with GST tag. The sequence is ISLKERKTDYECTGSNATYHGAKGEHTSRKDAMTAQNTGISTLYRNSYGAPAEDIKHNQV SAQPVPQEPSRKDYETYQPFQNSTRNYDESFFEDQVHHRPPASEYTMHLG

Conjugate

Alternative Names

CTNND2; catenin (cadherin-associated protein), delta 2; GT24; NPRAP; catenin delta-2; neurojungin; T-cell delta-catenin; catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein);

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.