KLH conjugated synthetic peptide, corresponding to between N terminal amino acids 10 - 39 of Human CTDSP2 (NP_005721.3).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/100 - 1/500.
Target
Alternative Names
CTDSP2; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; conserved gene amplified in osteosarcoma; NLI interacting factor 2; nuclear LIM inter
Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Pathway
Activation of Chaperone Genes by XBP1(S); Activation of Chaperones by IRE1alpha; BMP receptor signaling; Coregulation of Androgen receptor activity; Diabetes pathways; Disease; Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Citations
Publication ()
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COA
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