Anti-CPN1 monoclonal antibody (DCABH-11114) Made to order

Rabbit anti-Human CPN1 monoclonal antibody for ICC/IF, WB

View other CPN1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CPN1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CPN1; carboxypeptidase N, polypeptide 1; carboxypeptidase N, polypeptide 1, 50kD; carboxypeptidase N catalytic chain; anaphylatoxin inactivator; arginine carboxypeptidase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CPN1 (Carboxypeptidase N Subunit 1) is a Protein Coding gene. Diseases associated with CPN1 include carboxypeptidase n deficiency and pyelitis. Among its related pathways are Transport to the Golgi and subsequent modification and Prostate Cancer. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPXM2. Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.
Antigen Description
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. Carboxypeptidase N deficiency (CPND) [MIM:212070]: Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or asthma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Note=The disease is caused by mutations affecting the gene represented in this entry. Carboxypeptidase N catalytic chain is an enzyme that in humans is encoded by the CPN1 gene. 0The function about CPN1 antigen include metal ion binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding.

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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Karunakaran, KP; Blanchard, JF; et al. Molecular detection and seroepidemiology of the Chlamydia pneumoniae bacteriophage (Phi Cpn1). JOURNAL OF CLINICAL MICROBIOLOGY 40:4010-4014(2002).
Dang, X; Wuthrich, C; et al. JC Virus Encephalopathy Is Associated with a Novel Agnoprotein-Deletion JCV Variant. PLOS ONE 7:-(2012).

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