Anti-CPA6 monoclonal antibody (DCABH-11111) Made to order

Rabbit anti-Human CPA6 monoclonal antibody for WB, ELISA

View other CPA6 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CPA6 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CPA6; carboxypeptidase A6; CPAH; carboxypeptidase B; ETL5; FEB11
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CPA6 (Carboxypeptidase A6) is a Protein Coding gene. Diseases associated with CPA6 include epilepsy, familial temporal lobe, 5 and febrile seizures, familial, 11. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA3. The protein encoded by this gene belongs to the family of carboxypeptidases, which catalyze the release of C-terminal amino acid, and have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Polymorphic variants and a reciprocal translocation t(6;8)(q26;q13) involving this gene, have been associated with Duane retraction syndrome.
Antigen Description
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA6, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al. , 2002 [PubMed 11836249]). Epilepsy, familial temporal lobe, 5 (ETL5) [MIM:614417]: A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature. Note=The disease is caused by mutations affecting the gene represented in this entry. Febrile seizures, familial, 11 (FEB11) [MIM:614418]: Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. Note=A chromosomal aberration involving CPA6 was found in a patient with Duane retraction syndrome. Translocation t(6;8)(q26;q13). Carboxypeptidase A6 (CPA6) is an metallocarboxypeptidase enzyme that in humans is encoded by the CPA6 gene. It is highly expressed in the adult mouse olfactory bulb and is broadly expressed in the embryonic brain and other tissues. 0The function about CPA6 antigen include metal ion binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding.

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Khaket, TP; Singh, J; et al. Enkephalin Degrading Enzymes: Metalloproteases with High Potential for Drug Development. CURRENT PHARMACEUTICAL DESIGN 18:220-230(2012).
Salzmann, A; Guipponi, M; et al. Carboxypeptidase A6 Gene (CPA6) Mutations in a Recessive Familial Form of Febrile Seizures and Temporal Lobe Epilepsy and in Sporadic Temporal Lobe Epilepsy. HUMAN MUTATION 33:124-135(2012).

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