Anti-COX7A2 (aa 1-56) polyclonal antibody

Species Reactivity

Human

Immunogen

COX7A2 (NP_001856, 1 a.a. ~ 56 a.a) partial recombinant protein with GST tag. The sequence is MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYR

Conjugate

Alternative Names

COX7A2; cytochrome c oxidase subunit VIIa polypeptide 2 (liver); VIIAL; COX7AL; COX7AL1; COXVIIAL; COXVIIa-L; cytochrome c oxidase subunit 7A2, mitochondrial; cytochrome c oxidase subunit VIIaL; cytochrome c oxidase subunit VIIa-L; hepatic cytochrome-c ox

Entrez Gene ID

UniProt ID

Antigen Description

Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14.

Pathway

Alzheimers disease; Cardiac muscle contraction; Cytochrome c oxidase; Electron Transport Chain.