Anti-COX15 monoclonal antibody (DCABH-11103) Made to order

Rabbit anti-Human COX15 monoclonal antibody for WB, ELISA

View other COX15 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human COX15 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast); COX15 (yeast) homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly protein COX15 homolog; cytochrome c oxidase subunit 15
Entrez Gene ID
UniProt ID

Product Background


Gene summary
COX15 (COX15 Cytochrome C Oxidase Assembly Homolog) is a Protein Coding gene. Diseases associated with COX15 include cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2 and leigh syndrome. Among its related pathways are Metabolism and AMPK Enzyme Complex Pathway. GO annotations related to this gene include cytochrome-c oxidase activity and oxidoreductase activity, acting on the CH-CH group of donors. Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region.
Antigen Description
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. Clinical features include microcephaly, encephalopathy, hypertrophic cardiomyopathy, persistent lactic acidosis, respiratory distress, hypotonia and seizures. Postmortem cardiac muscle studies show marked complex IV deficiency. Complex IV activity is only slightly decreased in the skeletal muscle. Note=The disease is caused by mutations affecting the gene represented in this entry. Leigh syndrome (LS) [MIM:256000]: An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. Cytochrome c oxidase assembly protein COX15 homolog is an enzyme that in humans is encoded by the COX15 gene. 0The function about COX15 antigen include catalytic activity; contributes_to cytochrome-c oxidase activity; cytochrome-c oxidase activity; oxidoreductase activity, acting on the CH-CH group of donors.
Pathway
Cytochrome c oxidase, organism-specific biosystem; Cytochrome c oxidase, conserved biosystem; Electron Transport Chain, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Oxidative phosphorylation, organism-specific biosystem; Oxidative phosphorylation, conserved biosystem; Porphyrin and chlorophyll metabolism, organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Petruzzella, V; Tiranti, V; et al. Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain. GENOMICS 54:494-504(1998).
Bareth, B; Dennerlein, S; et al. The Heme a Synthase Cox15 Associates with Cytochrome c Oxidase Assembly Intermediates during Cox1 Maturation. MOLECULAR AND CELLULAR BIOLOGY 33:4128-4137(2013).

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