Anti-COPZ2 monoclonal antibody (DCABH-11094) Made to order

Rabbit anti-Human COPZ2 monoclonal antibody for WB, ELISA

View other COPZ2 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human COPZ2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
COPZ2; coatomer protein complex, subunit zeta 2; coatomer subunit zeta-2; MGC23008; nonclathrin coat protein zeta COP; zeta 2 coat protein
Entrez Gene ID
UniProt ID

Product Background


Gene summary
COPZ2 (Coatomer Protein Complex Subunit Zeta 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). An important paralog of this gene is COPZ1. This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Antigen Description
This gene encodes a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. This gene is similar to a related family member, and the two encoded proteins form distinct isotypes of the coatomer protein complex. The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).

Citations


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References


Shtutman, M; Roninson, IB; et al. A subunit of coatomer protein complex offers a novel tumor-specific target through a surprising mechanism. AUTOPHAGY 7:1551-1552(2011).
Tsuruta, T; Kozaki, K; et al. miR-152 Is a Tumor Suppressor microRNA That Is Silenced by DNA Hypermethylation in Endometrial Cancer. CANCER RESEARCH 71:6450-6462(2011).

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