Anti-COPS7B monoclonal antibody (DCABH-1572) Knockout Validated

Rabbit anti-Human COPS7B monoclonal antibody for WB, IP, ICC/IF

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS7576
Species Reactivity
Mouse, Rat, Human
Immunogen
A synthetic peptide corresponding to residues in Human CSN7b.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/10000 - 1/50000; IP: 1/100 - 1/500; ICC/IF: 1/50 - 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
COPS7B; COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis); COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 7B; COP9 signalosome complex subunit 7b; CSN7B; SGN7b
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. COP9 signalosome complex subunit 7b is a protein that in humans is encoded by the COPS7B gene.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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