Anti-COPS3 monoclonal antibody (CAB-5390MH)

Mouse anti-COPS3 monoclonal antibody for ELISA, WB, IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
MAAG2837
Species Reactivity
Human
Immunogen
COPS3 (NP_003644, 324 a.a.~423 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:500-1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
COPS3; COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis); COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 3; COP9 signalosome complex subunit 3; CSN3; SGN3
Entrez Gene ID
UniProt ID

Product Background


Gene summary
COPS3 (COP9 Signalosome Subunit 3) is a Protein Coding gene. Diseases associated with COPS3 include smith-magenis syndrome and cerebral palsy. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene.
Antigen Description
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene. It encodes a subunit of the COP9 signalosome. 0The function about COPS3 antigen include protein binding.
Pathway
TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem.

Citations


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References


Potocki, L; Glaze, D; et al. Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome. JOURNAL OF MEDICAL GENETICS 37:428-433(2000).
Both, J; Wu, T; et al. Identification of Novel Candidate Oncogenes in Chromosome Region 17p11.2-p12 in Human Osteosarcoma. PLOS ONE 7:-(2012).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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