Anti-COL12A1 polyclonal antibody (DPABH-16523)

Rabbit anti-Human COL12A1 (aa 768-892) polyclonal antibody for IHC-P

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
antigen sequence, corresponding to amino acids 768-892 of Human COL12A1.
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 1/20 - 1/50.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
COL12A1; collagen, type XII, alpha 1; COL12A1L; BA209D8.1; DJ234P15.1; collagen alpha-1(XII) chain
Entrez Gene ID
UniProt ID

Product Background


Gene summary
COL12A1 (Collagen Type XII Alpha 1) is a Protein Coding gene. Diseases associated with COL12A1 include bethlem myopathy 2 and ullrich congenital muscular dystrophy 2. Among its related pathways are Degradation of the extracellular matrix and ERK Signaling. GO annotations related to this gene include extracellular matrix structural constituent conferring tensile strength. An important paralog of this gene is MATN1. This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified.
Antigen Description
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. Bethlem myopathy 2 (BTHLM2) [MIM:616471]: A form of Bethlem myopathy, a benign proximal myopathy characterized by early childhood onset and joint contractures most frequently affecting the elbows and ankles. Note=The disease is caused by mutations affecting the gene represented in this entry. Ullrich congenital muscular dystrophy 2 (UCMD2) [MIM:616470]: A form of Ullrich muscular dystrophy, a congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy. Collagen alpha-1(XII) chain is a protein that in humans is encoded by the COL12A1 gene. 0The function about COL12A1 antigen include extracellular matrix structural constituent conferring tensile strength.
Pathway
Collagen biosynthesis and modifying enzymes; Collagen formation; Extracellular matrix organization; Protein digestion and absorption.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Bader, HL; Keene, DR; et al. Zebrafish collagen XII is present in embryonic connective tissue sheaths (fascia) and basement membranes. MATRIX BIOLOGY 28:32-43(2009).

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