Anti-COG1 monoclonal antibody (DCABH-11076) Made to order

Rabbit anti-Human COG1 monoclonal antibody for WB, ELISA

View other COG1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human COG1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
COG1; component of oligomeric golgi complex 1; LDLB, low density lipoprotein receptor defect B complementing; conserved oligomeric Golgi complex subunit 1; KIAA1381; COG complex subunit 1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
COG1 (Component Of Oligomeric Golgi Complex 1) is a Protein Coding gene. Diseases associated with COG1 include congenital disorder of glycosylation, type iig and cerebrocostomandibular-like syndrome. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex.
Antigen Description
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. Congenital disorder of glycosylation 2G (CDG2G) [MIM:611209]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Clinical features of CDG2G include failure to thrive, generalized hypotonia, growth retardation and mild psychomotor retardation. CDG2G is biochemically characterized by a defect in O-glycosylation as well as N-glycosylation. Note=The disease is caused by mutations affecting the gene represented in this entry. Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene. 0The function about COG1 antigen include protein binding.

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Fotso, P; Koryakina, Y; et al. Cog1p plays a central role in the organization of the yeast conserved oligomeric golgi complex. JOURNAL OF BIOLOGICAL CHEMISTRY 280:27613-27623(2005).

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