Anti-CNTN4 monoclonal antibody (DCABH-11073) Made to order

Rabbit anti-Human CNTN4 monoclonal antibody for IHC-P, WB

View other CNTN4 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Rat, Human
Immunogen
A synthetic peptide of human CNTN4 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CNTN4; contactin 4; contactin-4; BIG 2; neural cell adhesion protein BIG-2; axonal-associated cell adhesion molecule
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CNTN4 (Contactin 4) is a Protein Coding gene. Diseases associated with CNTN4 include 3p- syndrome and spinocerebellar ataxia type 16. An important paralog of this gene is DSCAML1. This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants.
Antigen Description
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. Note=A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features. Contactin-4 is a protein that in humans is encoded by the CNTN4 gene.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Meinl, E; et al. Untapped targets in multiple sclerosis. JOURNAL OF THE NEUROLOGICAL SCIENCES 311:S12-S15(2011).
Lancaster, E; Dalmau, J; et al. Neuronal autoantigens-pathogenesis, associated disorders and antibody testing. NATURE REVIEWS NEUROLOGY 8:380-390(2012).

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