Anti-CLIC6 polyclonal antibody (DPABH-22292)

Rabbit anti-Human CLIC6 (aa 435-484) polyclonal antibody for WB Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to a region within the internal sequence amino acids 435-484 (RREDGEASEP RALGQEHDIT LFVKAGYDGE SIGNCPFSQR LFMILWLKGV) of Human CLIC6 (NP_444507).
Conjugate
Unconjugated

Applications


Application Notes
WB: 0.5 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CLIC6; chloride intracellular channel 6; CLIC1L; chloride intracellular channel protein 6; parchorin; chloride channel form A
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CLIC6 (Chloride Intracellular Channel 6) is a Protein Coding gene. Among its related pathways are Hepatic ABC Transporters and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include protein homodimerization activity and chloride channel activity. An important paralog of this gene is CLIC1. This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms.
Antigen Description
May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene. 0The function about CLIC6 antigen include D2 dopamine receptor binding; D3 dopamine receptor binding; D4 dopamine receptor binding; protein C-terminus binding.

Citations


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References


Diewald, L; Rupp, J; et al. Activation by acidic pH of CLC-7 expressed in oocytes from Xenopus laevis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 291:421-424(2002).
Marinovich, M; Viviani, B; et al. NF-kappa B activation by triphenyltin triggers apoptosis in HL-60 cells. EXPERIMENTAL CELL RESEARCH 226:98-104(1996).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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